Vamsi Nallapareddy

Vamsi Nallapareddy

Research Assistant at University College London

University College London

About

Hello! I am Vamsi Nallapareddy! I am currently working as a Research Assistant at the Orengo Laboratory under the supervision of Prof. Christine Orengo at University College London.

I worked on multiple projects during the course of my bachelor’s degree in different domains such as Computational Biology, Deep Learning, Computer Vision, Natural Language Processing, and Reinforcement Learning. Exploring these different fields has helped me find a passion for the application of deep learning techniques to learn more from biological data in order to build applications and tools that can make a positive impact in the world.

Apart from my academic work, I like to read books, design, and write.

I am actively looking for Ph.D. opportunities starting in the Fall of 2022. Please feel free to get in touch with me if you want to have a chat!

Interests
  • Computational Biology
  • Bioinformatics
  • Deep Learning
Education
  • B.E. in Computer Science, 2021

    BITS Pilani - Hyderabad

Experience

 
 
 
 
 
Research Assistant
Jun 2021 – Present London, the UK

Supervisor: Prof. Christine Orengo

Projects:

  • CATHe: Remote homologue detection using embeddings from protein langauge models [In collaboration with Dr. Sameer Velankar’s Lab, EMBL-EBI & Prof. Burkhard Rost’s Lab, Technical University Munich]
  • Study of TriTerperne Synthase (TTS) enzymes [In collaboration with Prof. Janet Thornton’s Lab, EMBL-EBI & Prof. Anne Osbourn’s Lab, the John Innes Institute]
 
 
 
 
 
Bachelor’s Thesis Student
Jan 2021 – May 2021 London, the UK

Supervisor: Prof. Christine Orengo

Projects:

  • Deep learning based classification of protein sequences into CATH Structurally Similar Groups (SSGs) [In Collaboration with Prof. Burkhard Rost’s Lab, Technical University Munich]
  • Protein melting point prediction using deep learning [In collaboration with Prof. Florian Hollfelder’s Lab, Cambridge University]
 
 
 
 
 
Research Intern
Jul 2020 – Sep 2020 Pittsburgh, the USA

Supervisor: Prof. Min Xu

Project: Studying Computer Vision techniques to classify biological molecules in a Cryo-ET tomogram

 
 
 
 
 
Research Assistant
Jun 2020 – Nov 2020 Stockholm, Sweden

Supervisor: Prof. Arne Elofsson

Project: Protein inter-residue distance prediction using features derived from Multiple Sequence Alignments (MSA)

 
 
 
 
 
Research Assistant
Jun 2020 – Nov 2020 Ljubljana, Slovenia

Supervisor: Prof. Peter Peer

Project: Designing a deep learning based model to diagnose COVID-19 from Chest X-Ray (CXR) data

Awards

BITS Pilani Merit Scholarship
  • Awarded the university merit based scholarship for being in the top 1% of my cohort.
National Talent Search Examination (NTSE) Scholar
  • Recipient of the prestigious National Talent Search Examination (NTSE) scholarship provided by the Government of India
  • This scholarship provides a monthly stipend to the recipient till the end of their education.

Projects

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Adaptive Bitrate Estimation using Reinforcement Learning

Adaptive Bitrate Estimation using Reinforcement Learning

Advanced the state-of-the-art A3C model implemented in Pensieve by increasing exploration using the Follow then Forage technique

m6A Site Prediction

m6A Site Prediction

Trained a deep learning model to identify N6-MethylAdenosine (m6A) modifications in an RNA sequence

ABLE

ABLE

An Attention Based Learning method for Enzyme Classification using protein sequences

COVID-19 Diagnosis

COVID-19 Diagnosis

Designed an deep learning model to diagnose COVID-19 from Chest X-rays

Player Detection in Football Match Videos

Player Detection in Football Match Videos

Constructed a deep learning model to detect, classify, and track players in a football match video

Tomogram Analysis

Tomogram Analysis

Classified sub-tomograms according to the biomolecules present in them using various deep learning techniques

DeepCys

DeepCys

Deep learning based system to predict four different cysteine post-translational modifications

Serine Repeat Antigen 5 (SERA5) and Egress

Serine Repeat Antigen 5 (SERA5) and Egress

Conducted protein-protein docking simulations to understand the role of SERA5 and SERA6 in the process of egress, pertinent to the malaria parasite Plasmodium falciparum

Inter-Residue Distance Prediction

Inter-Residue Distance Prediction

Designed multiple deep learning models to predict the pair-wise distances for all the residues in a protein

Recent Publications

(2021). ABLE: Attention Based Learning for Enzyme Classification. In CBAC.

Cite Manuscript

(2021). Improvements in CATH-Gene3D v4.3 and its applications to diverse sets of proteins. In CBCB 2021.

(2020). Efficient Cryo-Electron Tomogram Simulation of Macromolecular Crowding with Application to SARS-CoV-2. In IEEE BIBM 2020.

Cite Manuscript